Peer Reviewed Journal
2024, Vol. 7, Issue 2, Part A
Role of miR-496 in prediction of type 2 diabetes mellitus in Iraqi patients
Author(s)
Ammar Gany Yassin
Ammar Gany Yassin
Abstract
Background: Diabetes mellitus is a metabolic disease. Non-insulin dependent diabetes mellitus which also known as type 2 diabetes (T2DM) is its common form, its percentage might proceed 90-95% of all diabetic cases. This disease increases rapidly over short period of time and now a days younger age people might facing this problem even with low body mass index. According to cultural, socioeconomic, ethnic condition and degree of urbanization, the epidemic is varied. MicroRNA-496 (miR-496) is one of the well-known miRs enrolled the inflammatory signaling pathway and recently it has been discovered as epigenetic changes contributor for the development of diabetes in the pre-diabetic stage.
Background: Diabetes mellitus is a metabolic disease. Non-insulin dependent diabetes mellitus which also known as type 2 diabetes (T2DM) is its common form, its percentage might proceed 90-95% of all diabetic cases. This disease increases rapidly over short period of time and now a days younger age people might facing this problem even with low body mass index. According to cultural, socioeconomic, ethnic condition and degree of urbanization, the epidemic is varied. MicroRNA-496 (miR-496) is one of the well-known miRs enrolled the inflammatory signaling pathway and recently it has been discovered as epigenetic changes contributor for the development of diabetes in the pre-diabetic stage.
Objectives: Evaluate the sera levels of miR-496 in prediabetic T2DM patients and investigate the relationship between prediabetic state and level of miR-496 gene expression.
Methods: This study was carried at Al-Hussan endocrinology center in Kerbala Provence in Iraq during the period from Oct, 2022 to April, 2023 on 70 patients with impaired fasting glucose level (34 males and 36 females) and 50 apparently healthy subjects (24 males and 26 females) who were dealt with as control group. Two ml of sera were collected from obese prediabetic patients (BMI ≥ 30, fasting serum glucose level 110-140 mg/dl) each patient / control subjects were investigated to detect miR-181b expression level with real time PCR.
Results: The results of the present study revealed a significant decline in mean of sera levels for miR-496 in prediabetic patients group in comparison with its levels in control group (p value ≤ 0.05).
Conclusion: miR-496 could be used as a novel diagnostic biomarker to predict diabetes in prediabetic state. Hence, to prevent diabetes by changing the life style or by using certain medications.
Pages: 20-24 | Views: 283 | Downloads: 129
How to cite this article:
Ammar Gany Yassin. Role of miR-496 in prediction of type 2 diabetes mellitus in Iraqi patients. Int J Paediatrics Geriatrics 2024;7(2):20-24. DOI: 10.33545/26643685.2024.v7.i2a.237
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