2024, Vol. 7, Issue 2, Part A

Background: Chronic kidney disease is a progressive condition characterized by functional and structural alterations of the kidney, Coenzyme Q10 is a lipophilic molecule that plays a vital role in cellular energy generation while having an important anti-inflammatory and antioxidant actions, an adequate supply of Coenzyme Q10 is crucial for maintaining physiological functions of the mitochondria.

Aims of the study: To observe the status of patients affected by chronic kidney disease clinically after starting them on Coenzyme Q10 enzyme supplement, and to compare their renal function, inflammatory markers, cardiac function before, during and after starting them on Coenzyme Q10 supplement.

Patients and methods: A prospective study was done which included forty patients between the ages of five years to eighteen years, with chronic kidney disease, they were started on Coenzyme Q10 supplement for the duration of six months, the duration of the study was a year and a half, during that period their clinical status was monitored, measurement of multiple parameters, including blood pressure, heart rate and weight was done, blood and urine sampling for multiple investigations of certain markers was also performed, an echocardiography was done for all participants before, during and the end of the study to monitor their clinical response and any hospital admission during that time was registered.

Results: According to the sex of the patients, 57.5%were females, regarding hemodialysis, 50% of them were on hemodialysis, after starting Coenzyme Q10, blood urea levels showed a decline, while serum creatinine values remained constant, no significant changes were observed in serum calcium and parathyroid hormone values while serum phosphorus values increased, body weight, blood pressure and ejection fraction was unchanged during the study while proteinuria declined, 25% of patients were admitted to the hospital (15% admitted once, 5% twice and 5% were admitted three times).

Conclusions: There was a decrease in blood urea, the values of serum cholesterol also declined and a decrease in protein in urine was noticed in patients after Coenzyme Q10 was administrated.