International Journal of Paediatrics and Geriatrics

International Journal of Paediatrics and Geriatrics

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2024, Vol. 7, Issue 1, Part A

Clinical and biochemical liver derangements in Patients with Kala azar before starting treatment
Author(s)
Ali RB Musa, Sabih S Mehdi and Zainab Khairalla Fakhri
Abstract
Background: Kala-azar is an important parasitic disease that affects children of all age groups, it is caused by Leishmania species and transmitted by sand fly. The aim of study is to identify the clinical features and biochemical derangements of the liver in patients with kala azar before starting treatment.
Method: A hospital-based cross-sectional research was undertaken on 33 patients with clinical and lab diagnoses of kala azar at Babylon Teaching Hospital for Gynecology and Pediatrics in Hilla from January 2013 to January 2014. A case investigation form collected epidemiological, clinical, and laboratory data. Pre-treatment lab testing assessed liver dysfunction in these individuals. A bone marrow aspiration was utilized to diagnose.
Results: Thirty-three kala azar patients were investigated clinically and laboratory. The majority of 33 patients were under 2 years old. It was 1:1.4, with 19 men and 14 women. Nearly all patients had fever, 91% had splenomegaly, and 70% had hepatomegaly. At diagnosis, half of patients showed biochemical liver function abnormalities and 9% had acute liver failure.
Conclusion: Liver involvement is found in some patients both by clinical and biochemical markers. Some patients presented with features of acute hepatic failure before starting treatment.

Pages: 59-63 | Views: 397 | Downloads: 190


International Journal of Paediatrics and Geriatrics
How to cite this article:
Ali RB Musa, Sabih S Mehdi, Zainab Khairalla Fakhri. Clinical and biochemical liver derangements in Patients with Kala azar before starting treatment. Int J Paediatrics Geriatrics 2024;7(1):59-63. DOI: 10.33545/26643685.2024.v7.i1a.227
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