2020, Vol. 3, Issue 1, Part B
Unfolding the perinatal factors that affect cord blood thyroid stimulating hormone levels- an experience from a rural centre in southern India
Author(s)
Dr. Mounika Katyayani K, Dr. Kanta Kumari P, Dr. Vijaya Laxmi B and Dr. Laxmi Sravanthi N
Dr. Mounika Katyayani K, Dr. Kanta Kumari P, Dr. Vijaya Laxmi B and Dr. Laxmi Sravanthi N
Abstract
Objective: To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormone (CB-TSH) levels and examining the influence of maternal and perinatal factors on these levels in our cohort of babies. Design: A cross-sectional study. Setting: Tertiary care teaching hospital, China Kakani, A.P. Methods: CB-TSH levels were measured in 2012 live-born neonates using electro chemiluminescence immunoassay. The effect of various maternal and perinatal factors on CB-TSH levels was analyzed statistically by multivariate analysis. Results: The mean CB-TSH was 8.86 micro IU/ml (ranged between 0.23 to 100micro IU/ml). The incidence of high CB-TSH (>20microIU/ml) was 4.82%. CB-TSH levels were significantly raised in neonates delivered in 1st and 2nd birth order, assisted vaginal deliveries, need for emergency section, and who were born with low APGAR scores (p<0.01 and Cron-bach's alfa 0.932). Maternal hypothyroidism or maternal hypertension, weight appropriateness for gestation, birth weight and gestational age had no significance. Conclusion: Upon multivariate analysis, the need for resuscitation, mode of delivery, and birth order were found to be significant factors affecting CB-TSH levels. Hence, these factors must be considered cautiously while interpreting CB-TSH values.
Objective: To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormone (CB-TSH) levels and examining the influence of maternal and perinatal factors on these levels in our cohort of babies. Design: A cross-sectional study. Setting: Tertiary care teaching hospital, China Kakani, A.P. Methods: CB-TSH levels were measured in 2012 live-born neonates using electro chemiluminescence immunoassay. The effect of various maternal and perinatal factors on CB-TSH levels was analyzed statistically by multivariate analysis. Results: The mean CB-TSH was 8.86 micro IU/ml (ranged between 0.23 to 100micro IU/ml). The incidence of high CB-TSH (>20microIU/ml) was 4.82%. CB-TSH levels were significantly raised in neonates delivered in 1st and 2nd birth order, assisted vaginal deliveries, need for emergency section, and who were born with low APGAR scores (p<0.01 and Cron-bach's alfa 0.932). Maternal hypothyroidism or maternal hypertension, weight appropriateness for gestation, birth weight and gestational age had no significance. Conclusion: Upon multivariate analysis, the need for resuscitation, mode of delivery, and birth order were found to be significant factors affecting CB-TSH levels. Hence, these factors must be considered cautiously while interpreting CB-TSH values.
Pages: 107-112 | Views: 2618 | Downloads: 1267
How to cite this article:
Dr. Mounika Katyayani K, Dr. Kanta Kumari P, Dr. Vijaya Laxmi B, Dr. Laxmi Sravanthi N. Unfolding the perinatal factors that affect cord blood thyroid stimulating hormone levels- an experience from a rural centre in southern India. Int J Paediatrics Geriatrics 2020;3(1):107-112. DOI: 10.33545/26643685.2020.v3.i1b.69
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